A mechano-osmotic feedback couples cell volume to the rate of cell deformation

A mechano-osmotic feedback couples cell volume to the rate of cell deformation

Blog Article

Mechanics has been a central focus of physical biology in the past decade.In comparison, how cells manage their size is less understood.Here, we show that a parameter central to both the physics and the popularfilm.blog physiology of the cell, its volume, depends on a mechano-osmotic coupling.We found that cells change their volume depending on the rate at which they change shape, when they spontaneously spread or when they are externally deformed.Cells undergo slow deformation at constant volume, while fast deformation leads to volume loss.

We propose a mechanosensitive pump and cga 200 to cga 510 adapter leak model to explain this phenomenon.Our model and experiments suggest that volume modulation depends on the state of the actin cortex and the coupling of ion fluxes to membrane tension.This mechano-osmotic coupling defines a membrane tension homeostasis module constantly at work in cells, causing volume fluctuations associated with fast cell shape changes, with potential consequences on cellular physiology.